About Book
The Text Book of Medicinal Chemistry – III is a comprehensive guide designed to equip students with a deep understanding of modern chemotherapeutic agents, their chemical structures, and their relationships with pharmacological activity. It begins by thoroughly exploring antibiotics, detailing the historical development, nomenclature, stereochemistry, and structure-activity relationships (SAR) of vital classes such as β-lactams (penicillins, cephalosporins), aminoglycosides, tetracyclines, macrolides, and miscellaneous agents like chloramphenicol and clindamycin. The book provides valuable insights into chemical degradation and classification, enabling students to grasp the rationale behind drug design and modification. It also emphasizes the prodrug concept and its role in enhancing bioavailability and reducing toxicity.
The textbook moves on to antimalarial drugs, covering the etiology of malaria and the SAR of quinoline derivatives such as chloroquine, quinine, and primaquine. In-depth discussions on biguanides, dihydrotriazines, and newer antimalarials like artemether and atovaquone are included. The third chapter focuses on anti-tubercular agents, including both synthetic and antibiotic categories, addressing emerging drug resistance issues. It also covers urinary tract anti-infectives, especially fluoroquinolones and their evolution through SAR studies.
Antiviral agents form another significant section, with detailed coverage of nucleoside analogs, protease inhibitors, and other antiviral categories that target various stages of viral replication. This is followed by antifungal agents, encompassing both natural antibiotics and synthetic drugs used to treat systemic and topical fungal infections. The section on anti-protozoal agents includes drugs used for amoebiasis, leishmaniasis, and trypanosomiasis, while the anthelmintic chapter addresses helminthic infections using agents like albendazole and ivermectin.
The book also dives into sulfonamides and sulfones, exploring their chemistry, historical development, SAR, and therapeutic applications, along with folate reductase inhibitors like trimethoprim. Importantly, the book culminates with chapters on drug design principles, introducing quantitative structure-activity relationships (QSAR), physicochemical parameters, pharmacophore modeling, and molecular docking techniques. Finally, combinatorial chemistry is introduced to highlight high-throughput synthesis methods essential in modern drug discovery. Overall, this book serves as a vital academic and reference resource for pharmacy and medicinal chemistry students, bridging foundational knowledge with contemporary drug development approaches.
About Author
Dr. Satkar Prasad is presently working as Principal in RKDF School of Pharmaceutical Science, Bhabha University, Bhopal. He has completed his doctorate from Suresh Gyan Vihar University, Jaipur in 2020. His research domain is “Isolation, Structural studies in the Chemical Constituents & Pharmacological evaluation of Root & Leaf extract of Pavetta Indica linn”. He has completed his M.Pharm in Pharmaceutical Chemistry in 2009 from Dr. M.G.R. Medical University, Chennai. He has published More than 120 publications in National & International journals of repute. He has published more than 30 Papers in National & international conferences. He has guided 12 Research Scholar from them 06 Research Scholar has awarded the PhD. He has Guided more than 40 Post graduate students. He has Published 05 Patent & 02 Books. He is life time member of “Association of Pharmaceutical Teacher of India”. Rashtriya Samta Swatantra Manch honors him with “Shikshak Sri Award” on 5th September 2017 at New Delhi by the Vice Chancellor of Delhi University for Outstanding work in the Field of Teaching. He has endowed with Excellence in Education, Research and Innovation award from Research Innovation foundation, Bhopal & Scan Research Laboratories on13th November 2022 at MPCST, Bhopal.
Prof. Dr. Ganesh S. Andhale completed his B. Pharm. in 2008 from Pravara Rural College of Pharmacy, Pravaranagar (Pune University, Pune), M. Pharm. in 2010 from Acahrya & B M Reddy College of Pharmacy, (Rajiv Gandhi University of Health Sciences [RGUHS], Bangalore), He earned his Ph. D. in 2019 from Rajiv Gandhi University of Health Sciences, Bengaluru. He also has completed Professional Diploma in Clinical Research from Clinical Catalyst, Pune. He has completed the Short Course in Educational Methodology from RGUHS, Bangalore. Presently, Prof. Dr. Ganesh S. Andhale is working as Professor, and Head Department of Pharmaceutical Chemistry at ALARD College of Pharmacy, Pune. He was a recognized guide for post graduate research in RGUHS and he is recognized guide for M. Pharm and PhD in SPPU. Pune His area of research includes prodrugs, codrugs design and synthesis of various molecules of pharmacological interest. He has published more than 35 papers in international and national journals of repute, presented papers at various national and international conferences and seminars. He received the Distinguished Alumni Award, Best Teacher Award, Best HoD Award and All-rounder faculty of the year award. He was the Co-opt Member of the IPA-Karnataka State Branch. He also was an Executive Council [EC] Member of Indian Pharmaceutical Association [IPA] Peenya branch. Presently he is the Co-opt Member of IPA-Pune Local branch. He is the Life Member of IPA, APTI, and ISTE.
Mr. Ashok A. Chopane is presently working as an Assistant Professor, Dharmaraj Shaikshanik Pratishthan's College of Pharmacy, Ahmednagar. He has three years of teaching and research experience. He has completed his B. Pharm ACS's College of Pharmaceutical Science & Research, Ashti [Affiliated with Dr. Babasaheb Ambedkar Marathwada University Aurangabad]. and M. Pharm in Department of pharmaceutical chemistry from Dr. Vithalrao Vikhe Patil Foundation's College of pharmacy, Vilad Ghat, Ahmednagar [Affiliated with Savitribai Phule Pune University, Pune]. He has published Patents, Books & Several research and review papers in international journals of repute and also attends various International and National seminars/Conferences/FDPs/Workshops.
Dr.Preeti Bhadauria M.Pharm, Ph.D, is associate Professor and Head of Pharmaceutical Chemistry Department at Nova College of Pharmacy, Lucknow. I have more than 11 years in academic experience and am a life member of APTI. I have attended various National and international conferences.I have published various research papers and also have a Various Patent work.
Dr. Prateek Porwal is an accomplished academician with a strong foundation in pharmaceutical sciences, holding an M.Pharm in Pharmaceutical Chemistry and a Ph.D. in the same discipline. He currently serves as an Associate Professor at FS College of Pharmacy and Research Centre, FS University, Shikohabad, Uttar Pradesh. With a deep commitment to research and education, Dr. Porwal has guided numerous students and contributed significantly to the field through his scholarly work. His expertise lies in Medicinal chemistry, Drug design & development, Molecular docking, and the development of novel therapeutic agents. He is actively involved in academic collaborations and research publications..
