ISBN : 978-93-7462-427-2
Category : Academic
Catalogue : Medical And Nursing
ID : SB22392
TEXT BOOK OF BIOCHEMISTRY
According to latest syllabus of NEP-2020 of Under Graduate and Post Graduate students
Ritika Parashar, Khushboo Vyas, Deepanshu Sharma, Dr. Arun Sharma, Dr. Manish Kumar
Paperback
999.00
e Book
699.00
Pages : 278
Language : English
About Book
The Text Book of Biochemistry is a comprehensive and systematically organized academic resource designed to provide students with a fundamental understanding of biochemical principles and their applications in pharmaceutical and medical sciences. The book presents essential concepts of biochemistry in a simple, clear, and scientifically accurate manner, making it suitable for undergraduate students of pharmacy, medical, and allied health sciences. It provides a balanced integration of theoretical knowledge, biochemical mechanisms, metabolic pathways, and clinical applications. The book begins with an introduction to enzymology, covering the properties, classification, nomenclature, and biological significance of enzymes and coenzymes. It explains enzyme kinetics, Michaelis–Menten and Lineweaver–Burk plots, enzyme inhibition, and regulatory mechanisms. Special emphasis is placed on the therapeutic and diagnostic applications of enzymes and isoenzymes. The clinical chemistry section introduces important laboratory investigations, including liver function tests, renal function tests, and enzyme-linked immunosorbent assay (ELISA). It also describes the digestion and absorption of nutrients, the biochemical roles of vitamins and minerals, and disorders associated with nutritional deficiencies. The subsequent sections provide a detailed understanding of biomolecules, bioenergetics, carbohydrate metabolism, and biological oxidation. Important metabolic pathways, including glycolysis, the citric acid cycle, gluconeogenesis, the hexose monophosphate shunt, and glycogen metabolism, are explained with their physiological significance. The book also highlights the regulation of blood glucose, metabolic changes during fasting and starvation, and biochemical abnormalities associated with diabetes mellitus. The electron transport chain, oxidative phosphorylation, ATP synthesis, and mitochondrial dysfunction are discussed to establish a clear understanding of cellular energy production. The section on lipid metabolism explains the classification, biological functions, digestion, and metabolic significance of lipids and lipoproteins. It covers fatty acid oxidation, fatty acid synthesis, ketone body metabolism, cholesterol metabolism, and the clinical importance of lipid-profile parameters. Common metabolic disorders, including hyperlipidaemia, hypercholesterolaemia, atherosclerosis, fatty liver disease, and obesity, are discussed to connect biochemical processes with human health and disease. The book further explores amino acid and protein metabolism, including transamination, deamination, decarboxylation, and the urea cycle. It explains the metabolic fate of amino acids and important inherited metabolic disorders such as phenylketonuria, alkaptonuria, albinism, and tyrosinaemia. The biochemical significance of neurotransmitters and hormones derived from amino acids is also presented. Additionally, heme metabolism and the biochemical basis of jaundice are explained to strengthen the understanding of clinically relevant metabolic processes. The final section focuses on nucleic acid metabolism, molecular biology, and genetic information transfer. It describes purine and pyrimidine nucleotide biosynthesis, nucleotide degradation, hyperuricaemia, and gout. Fundamental concepts of genome organization, DNA replication, transcription, translation, and the genetic code are presented systematically. The book also introduces the regulation of protein synthesis, inhibitors of transcription and translation, DNA-repair mechanisms, and associated genetic disorders
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