About author : Prof. (Dr.) Rajesh Verma is a distinguished academic and Head of the Department of Pharmaceutical Chemistry at the NIMS Institute of Pharmacy, NIMS University, Rajasthan. With over 18 years of teaching experience, Dr. Verma has contributed extensively to the field through 35 research articles, a published book, and two patents. His work is recognized internationally, with active participation in 38 conferences, seminars, workshops, and FDPs. A seasoned educator and researcher, Dr. Verma continues to advance pharmaceutical sciences and mentor future professionals in pharmacy and pharmaceutical chemistry. Dr. Lubna Azmi is an Assistant Professor in the Department of Pharmaceutical Chemistry at the Institute of Pharmaceutical Sciences, University of Lucknow, with a robust background in drug discovery and targeted drug delivery. With over 50 international publications, she is recognized for her contributions to gastrointestinal tuberculosis research, funded by a 20 lakh grant from the SERB. Dr. Azmi’s research journey includes a National Postdoctoral Fellowship at CSIR-CDRI and a Ph.D. in natural product formulations from CSIR-NBRI. She has also been honored with the Bill & Melinda Gates Foundation Young Investigators Award and the TWAS Fellowship, highlighting her contributions to global health. Her research interests focus on drug discovery and combination therapies for tuberculosis, with an emphasis on both syntactical and natural products. Dr Kavita Shukla is working as Professor & Principal in Hitkarini College Of Pharmacy, Dumna Road, Jabalpur. Dr. Kavita Shukla, born and brought up in Jabalpur, completed her schooling at Christ Church Girls' Senior Secondary School. A B.Pharm Gold Medalist and GATE qualifier with 98.71 percentile, she holds a Master’s degree in Medicinal and Pharmaceutical Chemistry from SGSITS along with a Ph.D. in Pharmaceutical Sciences. With 11 patents and over 20 research publications, Dr. Shukla currently serves as the Prin

About book : The Text Book of Medicinal Chemistry-I offers an in-depth exploration of medicinal chemistry, aligning with the core curriculum for pharmacy and medicinal chemistry students. The book begins by detailing the history and evolution of medicinal chemistry, providing a foundation for understanding how drug properties influence biological action. Readers gain insights into key physicochemical concepts such as ionization, solubility, hydrogen bonding, and bioisosterism, essential for drug design. Following this introduction, the book covers drug metabolism processes, focusing on Phase I and Phase II reactions and factors influencing metabolic rates, including stereochemistry. The autonomic nervous system is extensively covered, with sections on adrenergic and cholinergic neurotransmitters, discussing their biosynthesis, metabolism, and receptor types. Each chapter delves into various drug classes such as sympathomimetic and parasympathomimetic agents, providing the mechanism of action, therapeutic uses, and Structure-Activity Relationship (SAR) insights. Key classes of drugs, including adrenergic antagonists, cholinergic blockers, sedatives, hypnotics, antipsychotics, anticonvulsants, general anesthetics, and analgesics, are systematically analyzed. Emphasis is placed on the synthesis and SAR of specific drugs marked with asterisks, aiding students in understanding the chemical intricacies and development of active compounds. Additional sections provide comprehensive coverage of sedatives, anticonvulsants, and anesthetics, offering readers an analytical view of their therapeutic action and SAR. Designed for in-depth study, this book is a critical resource for students aiming to grasp medicinal chemistry concepts, from foundational knowledge to advanced applications in drug synthesis and analysis.