About Book
The Textbook of Biochemistry is a comprehensive guide that explores the molecular basis of life, focusing on the structure, function, and metabolism of biomolecules. It begins with an introduction to biomolecules, discussing their classification and the chemical nature and biological roles of carbohydrates, lipids, nucleic acids, amino acids, and proteins. The chapter explains how these organic compounds serve as the building blocks of life, participating in structural formation, energy production, and genetic processes. The section on bioenergetics introduces the concept of free energy, distinguishing between endergonic and exergonic reactions, and explains the relationship among free energy, enthalpy, and entropy. It highlights redox potential and energy-rich compounds such as ATP and cyclic AMP, emphasizing their biological significance in energy transfer and cellular regulation. The carbohydrate metabolism chapter covers glycolysis, the citric acid cycle, and the HMP shunt in detail, describing their pathways, energetics, and physiological importance. It also discusses glycogen metabolism, gluconeogenesis, and the hormonal regulation of blood glucose, with clinical insight into diabetes mellitus and glycogen storage diseases. The next section, biological oxidation, explains the mechanisms of the electron transport chain and oxidative phosphorylation, along with substrate-level phosphorylation, inhibitors, and uncouplers that affect energy production. The lipid metabolism chapter elaborates on β-oxidation of fatty acids, ketone body formation, fatty acid synthesis, and cholesterol metabolism, including its conversion to bile acids, steroid hormones, and vitamin D, while addressing disorders like atherosclerosis and fatty liver. The section on amino acid metabolism discusses reactions such as transamination, deamination, and decarboxylation, along with the urea cycle and its disorders. It also includes the catabolism of phenylalanine and tyrosine and their related diseases like phenylketonuria and albinism. Furthermore, it explains the biosynthesis and physiological roles of dopamine, serotonin (5-HT), melatonin, noradrenaline, and adrenaline, along with heme catabolism and jaundice. The nucleic acid metabolism chapter focuses on purine and pyrimidine nucleotide synthesis and degradation, hyperuricemia, and gout, while also detailing the structure and function of DNA and RNA. It further explores DNA replication, transcription, the genetic code, and translation, including inhibitors of protein synthesis. The final section on enzymes describes their properties, nomenclature, and IUB classification, and explains enzyme kinetics using Michaelis and Lineweaver-Burk plots. It also covers enzyme inhibition, regulation through induction and allosteric control, and their therapeutic and diagnostic applications, including isoenzymes. Lastly, the role of coenzymes is detailed, explaining their structures and biochemical functions in catalysis. Overall, this textbook provides a deep and systematic understanding of biochemistry, integrating molecular concepts with physiological and clinical relevance for students and professionals in the life sciences.
About Author
Brijendra Kumar Kashyap is an Assistant Professor and Training and placement In-charge of Biotechnology Engineering, Bundelkhand University, Jhansi, Uttar Pradesh, India. Dr. Kashyap’s educational journey includes undergraduate and postgraduate studies at Banaras Hindu University. He has received various prestigious awards, including the Young Scientist Award from SBBS India, Outstanding Achievement Award-2025 at international conference by Career Point University, India, JRF (NET)-CSIR, SRF-CSIR, SRF-ICAR, IITD Fellowship, ARS (NET)-ICAR, GATE, DBT Fellowship etc. With >16 years of research and teaching experience, at BHU, IIT-Delhi, NBAIM-ICAR, DRDE Gwalior, SHUATS-Prayagraj (Formerly AAIDU-Allahabad), Bundelkhand University, Jhansi, he published more than 35 articles in reputed and high IF (>5) journal, including Frontiers in Microbiology and Plant Science, ACS Omega, ESPR, with the H-index of 15 (830 citation), edited 2 international book in Springer Nature. He has been granted with 2 Indian and 1 German patent, 1 Indian copyright and the member of Indian J. of Microbiology (life time), SBBS-India (life time), American Society of Microbiology (ASM) since 2022, reviewers of >16 reputed journal, including American Chemical Society (ACS) Journals’, Royal Society of Chemistry (RSCs) Journals’, Frontiers in Microbiology, editor of 2 peer reviewed international journal, was the active member of MHRD funded TEQIP-III project of IET, BU, conducted 3 national conferences, invited as speaker at international conference of IABS-NZ 2024 by AIIMS, Delhi, chair the session as chairman in conference of FAVBS-2025, and honored with various prestigious recognition which brings valuable knowledge to academia and science.
Sagar Sharma is currently pursuing his Ph.D. in Microbiology at Gandhinagar University, Gujarat, India. He holds an M.Sc. in Microbiology from Charotar University of Science and Technology and a B.Ed. from Sabarmati University. His research experience spans international and industrial domains, including a tenure as a research student at the University of Silesia, Poland, and as part of the scientific team at Zydus Cadila Healthcare Ltd., India. Sagar has authored and co-authored publications in reputed journals such as American Journal of Cancer Research and Frontiers in Microbiology. His contributions to science include being granted a German patent for “Extended-release composition of berberine and sitagliptin for long-lasting antidiabetic effects” and receiving an Indian copyright for “Nanoparticle Based Drug Delivery Systems: Challenges, Benefits and Future Directions in Cancer.” His research interests cover environmental biotechnology, bioremediation, CRISPR/Cas9-mediated gene editing, and molecular biology-based approaches for human health and environmental betterment. Alongside research, he is an educator in Cambridge IGCSE and ICSE curricula, dedicated to inspiring the next generation of scientists.
Dr. R. Sathiyasundar is a distinguished Professor of Pharmaceutical Analysis and Pharmaceutical Chemistry at Cheran College of Pharmacy, Cheran Institute of Health Science, Coimbatore. With over 16 years of experience in both industry and academia, he has made significant contributions to pharmaceutical sciences. He earned his Ph.D. in 2018 from Annamalai University under the prestigious UGC-BSR fellowship. Dr. Sathiyasundar holds more than four Indian patents, reflecting his innovative research. He has also authored and published five textbooks in the pharmaceutical field, serving as valuable resources for students and professionals. His expertise and dedication continue to inspire the next generation of pharmacy professionals.
Mr. Laxman Prajapati is a dedicated pharmaceutical professional with a strong academic foundation in pharmaceutical chemistry. He is pursuing Ph.D. in Pharmaceutical sciences. He has completed his M. Pharm in Pharmaceutical Chemistry from Maharishi Arvind College of Pharmacy, Jaipur and B. Pharm from Swami Keshvanand Institute of Pharmacy, Jaipur. With one year of his teaching experience as an Assistant Professor at Sri Balaji College of Pharmacy he has nurtured many Pharmacy students. His research interests include Synthetic medicinal chemistry, Drug discovery and Process validation, with significant contributions in projects such as the Application of recombinant DNA (R-DNA) technology in medicinal chemistry and the Development and validation of RP-HPLC methods for Sorafenib in tablet dosage forms. This book reflects his dedication to advancing the field of Pharmaceutical Chemistry, providing insights that connect academic knowledge with real-world applications in drug development and process optimization.
Prof. (Dr.) Bhoomika is an esteemed academician and researcher, currently serving as a Professor at Department of Life Sciences, School of Biosciences & Technology (SBT), Galgotias University, Greater Noida (U.P.). With a strong foundation in education and a passion for research, she has carved a niche for herself in the field of Biosciences. She holds a doctoral degree from the renowned university, Banaras Hindu University (BHU), Varanasi, where she completed her PhD in 2013. Prior to this, she has received the degree of M.Sc. (Biochemistry) in 2005 and BSc (Zoology, Botany, Chemistry) in 2003 from Dr. Bhimrao Ambedkar University, Agra. Her commitment to academic excellence was further demonstrated through the qualification of National Eligibility Test (CSIR-UGC-NET) in June 2005 and Graduate Aptitude Test in Engineering (GATE) in 2005 and 2006. In addition to her academic achievements, Prof. Bhoomika is a recipient of prestigious accolades, including being awarded the National Post Doctoral Fellowship (N-PDF) from DST-SERB, Junior Research Fellowship (JRF) as well as Senior Research Fellowship (SRF) from DST and Research Fellowship from UGC. Her doctoral and post-doctoral research is majorly focused in the area of crop physiology and biochemistry. She has published her research work extensively in highly reputable journals and national/international conferences. Her research account is also feathered with several patents. She has an extensive experience of working at the laboratories of various premier institutes like National Institute of Plant Genome Research (NIPGR), New Delhi, Indian Agricultural Research Institute (IARI), commonly known as the Pusa Institute, New Delhi, Jawaharlal Nehru University, New Delhi, Banaras Hindu University, Varanasi, Defence Institute of Physiology and Allied Sciences (DIPAS), DRDO, Delhi for around 19 years. Her work has made significant contributions to the field, and she continues to inspire students and peers alike through her passion for teaching and research. Besides scholarly contributions in research, she is a distinguished teaching professional from around 12 years and has a vast experience of teaching a wide range of courses to BSc, MSc and PhD students viz. Biochemistry, Biomolecules, Cell Biology, Molecular Biology, Cytogenetics and Plant Breeding, Genetics, Genetic Disorders, Biology for Engineers, Environmental Science, Bioinstrumentation and Biotechniques, Bioinformatics and other allied courses. With her vast research and teaching experience, she has several edited and text books in her account. Her zeal of learning and polishing skills is prominent through her active participation in various training programs/refresher courses/short term certificate courses, time to time. With her wealth of knowledge, experience, and dedication to advancing the frontiers of knowledge, Prof. (DR.) Bhoomika remains a prominent figure in academia and research, shaping the future of students through her teaching, research, training programs and mentorship.
Dr. Pooja Jha is presently working as an Assistant Professor at Department of Food Technology, JAIN (Deemed-to-be University), Bengaluru, India. She completed her B. Tech in Food Technology from West Bengal University of Technology, M. Tech in Food Science and Technology from Sambalpur University and PhD. In Food Biotechnology from the prestigious Institute of Chemical Technology, Mumbai. Her academic achievements are complemented by hands-on industry experience and active participation in professional workshops and conferences. Her research domain includes exploring food for their essential nutrients, their health benefits, food supplements, and nutrient interactions. Her area of expertise also includes probiotics, synbiotics and biofilms.
