About Book
The Text Book of Advanced Pharmacology-I is a comprehensive guide designed for postgraduate and advanced undergraduate pharmacy and pharmacology students. It begins with an in-depth exploration of pharmacokinetics, discussing the movement of drugs through the body—covering absorption, distribution, metabolism, and elimination. The section also introduces linear and non-linear compartment models and emphasizes the clinical significance of protein binding. Moving forward, the book delves into pharmacodynamics, explaining how drugs exert their effects through receptor interactions, quantification of receptor binding, and the correlation between drug concentration and physiological response. A detailed discussion on receptor structure, functional classification, and mechanisms of drug action strengthens conceptual understanding.
The next section, neurotransmission, explains how nerve cells communicate, elaborating on neurotransmitters such as acetylcholine, adrenaline, histamine, serotonin, dopamine, GABA, glutamate, and glycine. It also covers non-adrenergic, non-cholinergic (NANC) systems and co-transmission mechanisms. In systemic pharmacology, the book provides a detailed analysis of the autonomic nervous system, including parasympathomimetic, parasympatholytic, sympathomimetic, and sympatholytic agents, along with drugs acting at the neuromuscular junction. The central nervous system pharmacology chapters are divided into three parts, covering general and local anesthetics, sedatives, hypnotics, anti-anxiety drugs, antidepressants, antipsychotics, antiepileptics, neurodegenerative disorders, and analgesics—both narcotic and non-narcotic.
The cardiovascular pharmacology section is equally detailed, spread across three chapters. It encompasses diuretics, antihypertensives, anti-ischemic drugs, and anti-arrhythmics in the first part; drugs for heart failure, antihyperlipidemics, and hematinics in the second; and coagulants, anticoagulants, fibrinolytics, and antiplatelet drugs in the third. Each topic integrates disease pathophysiology with the pharmacological profiles of existing and novel therapeutic agents. The final unit, autocoid pharmacology, offers insights into the physiological and pathological roles of histamine, serotonin, kinins, prostaglandins, opioid autocoids, and the pharmacology of 5-HT and its antagonists.
About Author
Ms.Supriya Singh is an Assistant Professor at Sunder Deep Global University, where she teaches B.Pharm and M.Pharm students, mentors research scholars, and guides postgraduate theses. She is actively involved in student counselling, curriculum development, and managing the animal house facility.Previously, she worked with Tata 1mg as a Senior Drug Data Analyst in Medical Affairs, where she was responsible for extracting information on OTC products from online sources and updating the product database, along with preparing safety-related documentation and supporting healthcare professionals with drug information.Currently pursuing her doctoral research at Sunder Deep Global University, she combines academic and industry experience to contribute to the advancement of pharmaceutical sciences.
Ms. Susheela Kumara is working as an Associate Professor in Abhilashi College of Pharmacy Ner Chowk, Mandi H.P.. She is 10 years teaching experience and 1 year industrial experience. Completed B. Pharm from Abhilashi College Of Pharmacy (H.P.T.U.) M.Pharm from Shoolini University Solan (H.P.) Pursuing P.H.D (Department of Pharmacology) Area of interest Neuropharmacology, Cardiovascular Pharmacology, Neuropathic Pharmacology.Worked as a central Superintendent in H.P.T.U. Hamirpur H.P. Worked as an Evaluator for answer scripts for Himachal Pradesh University, for degree level. Participated in many national and International Conferences, seminars and Workshops. Published several Papers in National and International Journals.
Ms. Nishi Shukla, M. Pharm, is an Asst. Professor in Era College of Pharmacy, Era University, Lucknow, (U.P.). She has completed her under graduation from Advance Inst. Of Biotech and Paramedical Sciences, Kanpur and post-graduation from SITM, Lucknow. She has initially served as a lecturer in Aryakul Group of Colleges, Lucknow then appointed as Assistant Professor in Department of Pharmacy, Babu Banarasi Das Northern India Institute of Technology, Lucknow. Ms. Nishi has filed few patents and also published papers in different national and international journals.
Mrs. Preet Kaur is a pharmaceutical professional with over 10 years of combined experience in academia and the pharmaceutical industry. She obtained her Bachelor of Pharmacy (B.Pharm.) with First Division from Aryakul College of Pharmacy & Research, Lucknow, and her Master of Pharmacy (M.Pharm.) in Pharmaceutics with First Division from Babu Banarasi Das University, Lucknow. She is presently pursuing a Ph.D. in Pharmaceutical Sciences at Shri Ramswaroop Memorial University Lucknow. Simultaneously serving as Assistant Professor in the Department of Pharmacy at Ashoka Institute of Technology and Management, Varanasi. Her current research interests include solubility enhancement, co-crystallization, and nanoparticle-based formulations. She has published several research papers in reputed national and international journals and holds one patent in her area of specialization.
Dr. Abhishek Kumar is an accomplished academician and pharmaceutical professional with over 15 years of combined experience in teaching and the pharmaceutical industry. He earned his B.Pharm. (First Class with Distinction) from Bharati Vidyapeeth University (Pune), followed by an M.S. in Pharmaceutical Technology from Vinayaka Mission University (Hyderabad) and an M. Pharm. (First Division with Honours) from Babu Banarasi Das University (Lucknow). In June 2023, he was awarded a Ph.D. in Pharmaceutical Sciences by B.N. University (Udaipur), where his research focused on advanced drug‐delivery systems. Currently serving as Associate Professor and Head of the Department of Pharmacy at Ashoka Institute of Technology and Management, Varanasi, he has been instrumental in shaping future pharmacists since 2016. Dr. Kumar’s research focuses on novel drug delivery systems, gastro-retentive formulations, and various pharmaceutical drug developments, with 10 publications in reputed national and international journals. He has applied for one patent also.
