About Book
Text Book of Medicinal Chemistry – III is designed to provide comprehensive knowledge of chemotherapeutic agents with emphasis on their historical development, nomenclature, stereochemistry, structure–activity relationship (SAR), chemical degradation, classification, and important therapeutic products. The book begins with antibiotics, covering β-lactam antibiotics such as penicillins, cephalosporins, β-lactamase inhibitors, and monobactams, along with aminoglycosides and tetracyclines. It further discusses macrolides, miscellaneous antibiotics like chloramphenicol and clindamycin, and introduces the fundamental concepts of prodrug design. Detailed coverage of antimalarial drugs includes quinoline derivatives, biguanides, dihydrotriazines, and artemisinin compounds with emphasis on their SAR and mechanism of action. Anti-tubercular agents are explained under synthetic and antibiotic classes, along with urinary tract anti-infectives and quinolone derivatives. The section on antiviral agents highlights drugs used against influenza, herpes, and HIV infections, focusing on nucleoside analogues and protease inhibitors. Antifungal agents, both antibiotic and synthetic, are described with their structural features and pharmacological importance. The text also includes anti-protozoal agents and anthelmintics used in parasitic infections, detailing their chemistry and therapeutic applications. Sulphonamides and sulfones are discussed with their historical background, classification, and folate reductase inhibition mechanism. The final chapters introduce modern concepts of drug design, including QSAR parameters such as partition coefficient, Hammett and Taft constants, and Hansch analysis. Pharmacophore modeling, molecular docking, and combinatorial chemistry approaches are also explained, providing students with insight into contemporary drug discovery techniques. Overall, the book integrates classical medicinal chemistry with modern computational and synthetic strategies, making it highly relevant for advanced pharmacy education.
About Author
Dr. Noel Rahul Shaw is Doctorate in Pharmacy. He did his B.Pharm.in the year 1995 from University of Rajasthan, Jaipur, M.Pharm. from Jai Narain Vyas University, Jodhpur and Ph.D from Rajasthan University of Health Sciences, Jaipur. He also holds PG diploma in Marketing management from Bhartiya Vidhya Bhawan. He has twenty eight years of industrial and academic experience. He worked in industries of repute like Core health care, Claris Life sciences and Zydus Cadila in Product Management. Presently he is working as Associate Professor and Head, department of Pharmaceutical Chemistry, Lachoo memorial college of Science and Technology, Jodhpur. He has mentored many M.Pharm. Students and has published papers in journals of repute. He has also authored book on Modern Pharmaceutical Analytical Techniques for M.Pharm Students. He is a life member of APTI (Association of pharmaceutical teachers of India) and is vice president of LPPA (Lachoo Pharmacy Alumni association).
Mithilesh K. Narware is an accomplished academician and pharmaceutical professional with over fourteen years of experience in teaching and industry. He holds an M.Pharm in Pharmaceutical Chemistry and is currently pursuing a Ph.D. in Pharmaceutical Sciences. Presently, he serves as Associate Professor at Kailash Narayan Patel College of Pharmacy, Bhopal, affiliated with RGPV University. His expertise spans academic administration, PCI and RGPV documentation, examination conduct, and student career counseling. He has also gained valuable industrial experience as an IPQA Officer in the pharmaceutical sector. His research interests include analytical method development, particularly RP-HPLC and UV spectrophotometric estimation of pharmaceutical formulations.
Ms. Riddhi Modh is an Assistant Professor in Pharmaceutical Quality Assurance with a Master’s degree in Pharmacy (QA). She has professional experience in analytical research, quality control, and regulatory affairs for pharmaceutical products. Her expertise includes analytical method development, stability studies, and QbD-based approaches. She is actively involved in teaching, research, and academic writing in pharmaceutical sciences. Through her work, she aims to promote quality, innovation, and practical learning in pharmacy education.
Dr.Kandimalla Madhavi , working as Professor &Principal at M.R.R College of Pharmacy,Nandigama,Andhra Pradesh.She Completed her Ph.D from Andhra University in 2016.She got best Thesis award for her Ph.D Work in 2019.M.Pharmacy ,Pharmaceutical Chemistry from VEL’S College of Pharmacy, Pallavaram ,Chennai in 2007.B.Pharm from SVET College of Pharmacy,Humnabad,Karnataka in 2003.She has 19 Years of academic and research experience in the Specialization of Pharmaceutical Chemistry.She has guided over 70graduate students and 13 Post graduate students .She is life member of Association of Pharmaceutical teachers of India.She has published several National and International papers ,5Patents .She organized National seminars and presented posters in various conferences.
Dr. Pushpendra Kumar Jain is a distinguished academician with over 26 years of rich teaching experience in the field of Pharmaceutical Sciences. He holds a Doctorate in Pharmaceutical Sciences and has been consistently contributing to the academic and professional development of students through his deep knowledge, innovative teaching methods, and commitment to excellence. Throughout his career, Dr. Jain has played a pivotal role in nurturing young minds and shaping the future of pharmacy professionals. He is known for his dedication to quality education, academic leadership, and active involvement in research and institutional development. His extensive experience spans undergraduate and postgraduate teaching, curriculum development, and mentoring of research scholars. Dr. Jain’s contributions to the field of pharmacy education have made him a respected figure among peers and students alike. He remains passionate about advancing pharmaceutical education and continues to inspire future generations through his unwavering dedication and visionary approach.
