About Book
This textbook, Pharmaceutical Organic Chemistry, provides a comprehensive and systematic introduction to the fundamental principles of organic chemistry with special reference to pharmaceutical sciences. The book begins with the basic concepts of organic chemistry and explains the versatility of carbon through its tetravalency, catenation, and suitable atomic size. It introduces the classification and IUPAC nomenclature of aliphatic organic compounds in a clear and student-friendly manner. Important organic reactions such as addition, elimination, substitution, and rearrangement reactions are discussed with suitable examples. The formation, stability, and significance of reactive intermediates, including free radicals, carbocations, and carbanions, are also explained. The book highlights important electron displacement effects such as inductive, electromeric, mesomeric, and hyperconjugative effects and describes their role in determining the reactivity of organic compounds. The concept of hybridization and its significance in alkanes, alkenes, and alkynes are presented in detail. The chemistry of alkanes is covered through various methods of preparation, including the Wurtz reaction, Kolbe’s reaction, Clemmensen reduction, and Wolff–Kishner reduction. The free-radical substitution mechanism of alkanes is illustrated through halogenation reactions. Pharmaceutical applications of liquid paraffin, soft paraffin, and hard paraffin are also included. The section on cycloalkanes explains Baeyer’s strain theory, its limitations, the Coulson–Moffitt modification, and the Sachse–Mohr theory. The chemistry of alkenes includes their preparation by dehydration of alcohols, dehydrohalogenation of alkyl halides, dehalogenation of vicinal dihalides, and the Wittig reaction. Electrophilic addition reactions of alkenes are explained with reference to Markovnikov’s rule, anti-Markovnikov addition, hydration, and ozonolysis. The book also discusses the stability and reactions of conjugated dienes, including 1,2-addition, 1,4-addition, and the Diels–Alder reaction. The chemistry of alkyl halides is presented through detailed explanations of SN1, SN2, E1, and E2 reaction mechanisms. The influence of kinetics, substrate structure, solvent effects, and stereochemistry on substitution and elimination reactions is carefully described. Zaitsev’s rule and the competition between substitution and elimination reactions are explained with examples. The pharmaceutical applications of chloroform, iodoform, and trichloroethylene are also highlighted. The chemistry of benzene and its derivatives includes IUPAC nomenclature, resonance, molecular orbital structure, aromaticity, and Hückel’s rule. Important electrophilic aromatic substitution reactions, including nitration, halogenation, sulphonation, Friedel–Crafts alkylation, and Friedel–Crafts acylation, are explained systematically. The effect of substituents on the reactivity and orientation of monosubstituted benzene derivatives is also discussed. The final section focuses on carbonyl compounds such as aldehydes and ketones. It explains their preparation by oxidation of alcohols, the Reimer–Tiemann reaction, and Friedel–Crafts acylation. Important nucleophilic addition and condensation reactions, including aldol condensation, crossed aldol condensation, Cannizzaro reaction, crossed Cannizzaro reaction, benzoin condensation, and Perkin condensation, are described with suitable examples. Oxidation and reduction reactions of carbonyl compounds are also included. The pharmaceutical uses of compounds such as chloral, paraldehyde, and ketoprofen are discussed to connect theoretical concepts with practical applications. Overall, this book is designed to provide pharmacy students with a strong conceptual understanding of organic chemistry and its relevance to pharmaceutical compounds, drug development, and medicinal applications.
About Author
Dr. Manoj Shrawan Charde is presently serving as an Assistant Professor at Government College of Pharmacy, Chhatrapati Sambhajinagar. He completed his Diploma in Pharmacy from Smt. Kusumtai Wankhede Institute of Pharmacy and obtained his B.Pharm., M.Pharm., and Ph.D. degrees from the Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj Nagpur University. Dr. Charde has more than 20 years of experience in academics and pharmaceutical research. His major research interests include analytical method development, analytical evaluation, degradation studies, and impurity profiling of pharmaceutical drug molecules. He has published over 80 research papers in reputed national and international journals and has presented his research contributions at various scientific conferences and seminars. He has been awarded seven Indian patents for his innovative research work in the field of pharmaceutical sciences. Dr. Charde is also an active member of several professional and academic bodies related to pharmacy education and research.
Dr. Vidyasagar Matta is an Associate Professor at Sri Ranganayaka Swamy College of Pharmacy in Siddipet, Telangana. He earned his Ph.D. in 2025 from Career Point University (Kota, Rajasthan) and holds both an M.Pharm in Pharmaceutical Chemistry and a B.Pharm from Kakatiya University (Warangal). With a career spanning over 17 years, Dr. Vidyasagar has taught at several reputed institutions across Warangal and Karimnagar. His academic expertise lies in Pharmaceutical Organic Chemistry and Medicinal Chemistry, while his primary research interests focus on organic synthesis and stereochemistry. An active researcher, he has authored Twelve papers in reputed national and international journals, including two Scopus-indexed publications.
Dr. Vijay Kumar Bansal is Doctorate in Pharmacy. He did his B. Pharm from University of Rajasthan, Jaipur, M. Pharm from Jai Narain Vyas University, Jodhpur and Ph.D. from Rajasthan University of Health Sciences, Jaipur. He also pursued a diploma in management from IGNOU. He has nineteen years of professional experience, which includes academic and industrial exposures. Presently he is working as Associate Professor and Department In charge, department of pharmacology. He is a paper setter and examiner for various universities and has published research papers in journals of national and international repute. He qualified GPAT with 99.89 percentile. He has guided many UG and PG students.
Deepanshu Sharma is a dedicated academician and researcher in the field of Pharmaceutical Chemistry, currently serving as an Associate Professor. He holds an M.Pharm. degree and is pursuing his Ph.D., reflecting his strong commitment to higher education and research. With over 12 years of teaching and professional experience, he has contributed significantly to pharmaceutical education and academic development. He has published multiple research articles and holds patents, demonstrating his active involvement in innovation and scientific advancement. He has also participated in numerous conferences, workshops, and faculty development programs, enhancing his professional expertise. His areas of interest include medicinal chemistry, drug design, and pharmaceutical research, making him a valuable contributor to the academic and research community.
Dr. Ajay Gaur did B. Pharm. in 2001 and M. Pharm. in 2004 from Lachoo Memorial College of Science and Technology, Jodhpur & completed Ph.D. in 2009. I have also completed MBA in 2006 & PGDIPR in 2010 from IGNOU, Delhi. Currently I am working as an Associate Professor in Department of Pharmaceutical Chemistry in L.M. College of Sc. & Tech, Pharmacy wing, Jodhpur since 21/12/2010. I have 22 years teaching experiences after M.Pharm. and 1.4 years industrial experiences. I have guided at 12 PG and 2 Ph.D students. I am P.G. and Ph.D examiner of various universities. I have completed a major research project of AICTE in 2014. I have worked as a member of Academic Council, In-charge of QA & PMRA Department & have conducted various examinations in the capacity of Deputy Center Superintendent & Assistant Center Superintendent. I have worked as a convener of various committees like Glassware Purchase Coordination Committee, Literary & Scientific Planet Committee, Professional Bodies Committee, disciplinary committee, LPAEC etc. I have published 39 papers in various national/international journals, 1 book, 1 chapter in book and 34 abstracts in various national/international conferences. I have attended 35 international/national Conferences/Seminars/Symposiums & 21 SDP/training programmes. I am working as an editor and reviewer in various international and national journals. I am working as a Pharmacy Council of India Inspector, University Inspector & CPCSEA nominee. I have worked as a member of syllabus Committee of Faculty of Pharmacy, Rajasthan University of Health Sciences, Jaipur. I have got Certificate of Merit in Secondary (1992) by Ministry of H.R. & D. Govt. of India & N.C.C. "A Certificate in 1995. I have got best oral paper presentation award in National Conference in 2009 & first prize in Exit Exam in AICTE sponsored two weeks Staff Development Programme in 2019.
