ISBN : 978-93-7462-318-3
Category : Academic
Catalogue : Medical And Nursing
ID : SB21907
TEXT BOOK OF ADVANCE PHARMACOLOGY-I
According to latest syllabus of M.Pharm-I Semester of Pharmacy Council of India
Dharmendra Kumar, Dr Shweta Mishra, Dr. B. Sanjeeb Kumar Patro, Shreena Biyani, Dr. Abhishek Anand, Dr. D. Akiladevi
Paperback
899.00
e Book
399.00
Pages : 235
Language : English
About Book
This Text Book of Advance Pharmacology-I provides a comprehensive foundation in modern pharmacology by integrating fundamental principles with system-wise therapeutic applications. It begins with pharmacokinetics, explaining in detail how drugs are absorbed from various routes, distributed into different body compartments, biotransformed mainly by hepatic enzymes and finally eliminated through renal and non-renal pathways. The concepts of linear and non-linear compartment models are introduced to quantitatively describe drug disposition, and the clinical significance of protein binding is emphasized in relation to drug distribution, free drug concentration and potential interactions. The section on pharmacodynamics clarifies how drugs act at molecular targets, especially receptors, and how the relationship between drug concentration and effect governs potency, efficacy and safety. It describes the structural features of receptors, their functional families such as ion channel-linked, G-protein-coupled, enzyme-linked and nuclear receptors, and presents quantitative aspects of drug–receptor interaction and drug-elicited effects. A dedicated unit on neurotransmission explains the general aspects and sequential steps of synaptic transmission, covering synthesis, storage, release, receptor activation and inactivation of neurotransmitters. Neurohumoral transmission in the autonomic nervous system is discussed with special focus on acetylcholine and adrenaline, while central neurotransmission includes detailed study of histamine, serotonin, dopamine, GABA, glutamate and glycine, along with concepts of non-adrenergic non-cholinergic (NANC) transmission and co-transmission. Systemic pharmacology sections link pathophysiology with pharmacology of parasympathomimetics, parasympatholytics, sympathomimetics, sympatholytics and agents acting at the neuromuscular junction, highlighting both therapeutic uses and toxicological aspects. Central nervous system Pharmacology-I deals with the organization of the CNS and the pharmacology of general and local anaesthetics, as well as sedatives and hypnotics, explaining their mechanisms of action, clinical indications and adverse effects. Central nervous system Pharmacology-II focuses on drugs used in anxiety, depression, psychosis, mania and epilepsy, correlating disease mechanisms with drug targets and therapeutic strategies. A further CNS section covers neurodegenerative disorders and the pharmacology of narcotic and non-narcotic analgesics used for pain management. Cardiovascular Pharmacology-I encompasses diuretics, antihypertensives, anti-ischemic agents and anti-arrhythmic drugs, while Cardiovascular Pharmacology-II addresses drugs for heart failure, agents used in hyperlipidemia and hematinics for the management of different types of anemia. Cardiovascular Pharmacology-III elaborates on coagulants, anticoagulants, fibrinolytics and antiplatelet drugs, stressing their mechanisms, clinical indications and safety considerations. The final unit on autocoid pharmacology explains the physiological and pathological roles of histamine, serotonin, kinins, prostaglandins and opioid autacoids, and presents the pharmacology of 5-HT and its antagonists, linking receptor selectivity to therapeutic application. Overall, the book is structured to bridge basic science with clinical reasoning, enabling students to understand not only how drugs work but also why and when they are used in rational therapy.
Customer Reviews
