About Book
The Text Book of Medicinal Chemistry-I is a foundational academic resource tailored for undergraduate pharmacy and life science students. It begins with an insightful introduction to the history and development of medicinal chemistry, followed by an exploration of essential physicochemical properties—such as ionization, solubility, partition coefficient, and bioisosterism—that influence drug action. The book delves into drug metabolism, explaining both Phase I and Phase II reactions and emphasizing the stereochemical aspects affecting biotransformation. A significant portion is dedicated to the autonomic nervous system, detailing adrenergic and cholinergic neurotransmitters, their biosynthesis, metabolism, receptors, and drug interactions. Comprehensive coverage is given to sympathomimetic agents and adrenergic antagonists, including their classification, mechanism of action, and SAR. The cholinergic section spans both parasympathomimetic agents and cholinergic blockers, thoroughly explaining their pharmacological and structural aspects. Sedatives and hypnotics such as benzodiazepines and barbiturates are analyzed for their therapeutic role and SAR. Antipsychotic drugs, including phenothiazine derivatives and newer analogs, are presented with clarity. The anticonvulsant chapter includes barbiturates, hydantoins, and newer agents like gabapentin and valproic acid, along with mechanisms and SAR. The text also explains the classification and use of general anesthetics, including inhalation agents and dissociative anesthetics like ketamine. In-depth sections cover narcotic and non-narcotic analgesics, their SAR, mechanism, and therapeutic uses. It emphasizes both opioid agonists and antagonists, such as morphine and naloxone. The final chapter provides detailed information on anti-inflammatory drugs, including NSAIDs like aspirin, ibuprofen, and diclofenac. Throughout, the book emphasizes structure-activity relationships (SAR), mechanisms of action, and pharmacological applications. With drug examples and classifications well-integrated, this book provides a practical, application-oriented approach to medicinal chemistry. It is designed to help students connect chemical structures with pharmacological effects. Each chapter encourages critical thinking about how molecular features influence drug behavior. The text is organized logically, facilitating step-by-step learning of complex concepts. Additionally, it bridges the gap between basic science and clinical pharmacy, making it ideal for academic and exam preparation..
About Author
Dr. Prabhat Kumar Upadhyay is currently working as a Professor, in the Institute of Pharmaceutical Research, GLA University, Mathura, Uttar Pradesh. He completed M. Pharm. from Rajiv Gandhi University of Health Sciences Bangalore in 2006 and was awarded a Ph.D. in 2018. He has a total experience of more than 19 years in the research, academic and administration. His area of interest includes synthetic chemistry, molecular docking, phytochemistry, spectroscopic, and chromatographic techniques. Dr. Upadhyay is a well-known academician who is actively involved in the mentoring, training, and teaching of students and younger teams. He has guided more than 50 undergraduates, 8 post graduates, and two PhDs. Four Ph.D. scholars are working with him. He has published a total 86 papers of national and international repute, 03 book chapters, one book and two patents of IP Australia & IP India. He organized many conferences and workshops and participated in various conferences, workshops, short term courses, training programmes and faculty development programmes. He is the member of various associations and governing bodies. He is reviewer of various national and international journals. He serves the duties of as internal panel and external expert for board of studies (BOS) and Ph.D. thesis evaluator for many private and government universities.
Dr. Narsukumari Korrapati is an accomplished academician and researcher in the field of pharmaceutical chemistry, currently serving as an Associate Professor at A.M. Reddy Memorial College of Pharmacy, Narasaraopet. With a Ph.D. from Acharya Nagarjuna University, she brings a strong academic background, including a distinction-grade M.Pharmacy and a solid foundation in B.Pharmacy. Over the years, she has taught core subjects such as Medicinal Chemistry, Organic Chemistry, and Spectroscopic Techniques, showcasing her expertise and dedication to education. Her research work spans bioanalytical method development and drug analysis, with multiple publications in reputed journals including SCOPUS and UGC-listed titles. She has also guided numerous undergraduate and postgraduate projects, emphasizing practical and analytical skills. Dr. [Name] has actively participated in and contributed to national and international seminars and workshops, even organizing a workshop on molecular docking. Passionate, hardworking, and technically skilled, she continues to contribute significantly to the pharmaceutical sciences field.
Dr Pichika Mallikarjuna Rao is a Professor and Dean of Research at Newcastle University, UK (Malaysia Campus, NuMed). He has 35 years of teaching and Research experience, and his field of expertise is Drug Discovery.
Dr Balijepalli Madhu Katyayani is an Associate Professor at MAHSA University in Malaysia. She has 25 years of teaching and research experience and specialises in Ethnopharmacology
Dr Mak has 7 years of teaching and research experience. She is currently a Lecturer at IMU University, Kuala Lumpur, Malaysia, and is listed as a top 2% researcher. Her Specialisation is in the Integration of AI with CADD to find a solution for complex unmet health needs.
Dr. Vishal Trivedi is working as Professor in Madhav University, Faculty of Pharmacy, Pindwara (Sirohi). He has published 5 book, 3 Book Chapters and 22 research papers International/ National journals as well as having more 11 years teaching experience.