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ISBN : 978-93-6087-763-7

Category : Academic

Catalogue : Medical And Nursing

ID : SB21711

TEXT BOOK OF MEDICINAL CHEMISTRY-I

According to latest syllabus of B Pharm-IV of Pharmacy Council of India

Mr. Padol Shubham Gambhirrao; Ramakant Kashyap, Moni Rawat, Babita, Dr. Virendra Kumar Patel

Paperback

999.00

e Book

399.00

Pages : 295

Language : English

PAPERBACK Price : 999.00

About Book

Textbook of Medicinal Chemistry-I is a comprehensive guide that introduces pharmacy and pharmaceutical science students to the foundational concepts of medicinal chemistry. The book begins with a thorough exploration of the history and evolution of medicinal chemistry and emphasizes the significance of physicochemical properties like ionization, solubility, hydrogen bonding, and stereochemistry in determining biological activity. It details drug metabolism with a focus on Phase I and Phase II reactions and the various factors influencing metabolic processes, including stereochemical considerations. A substantial portion of the text is devoted to drugs acting on the autonomic nervous system, beginning with adrenergic neurotransmitters, their biosynthesis, catabolism, and receptor interactions. The classification, mechanism of action, structure-activity relationships (SAR), and therapeutic uses of both sympathomimetic and sympatholytic agents are covered extensively. Similarly, parasympathomimetic agents, their SAR, direct and indirect acting drugs, and cholinesterase inhibitors are explained in detail. Cholinergic blocking agents, both natural and synthetic, are discussed with emphasis on their mechanism and therapeutic potential. The book proceeds to discuss the classification and mechanism of sedatives and hypnotics, focusing on benzodiazepines and barbiturates, supported with SAR and drug examples. Antipsychotics, including phenothiazines, thioxanthenes, and newer atypical agents, are described with clarity regarding their action on CNS receptors and clinical relevance. The anticonvulsants section presents traditional and modern drugs categorized by chemical class, mechanisms, and structural relationships that impact efficacy and safety. General anesthetics are outlined through their classification into inhalation agents, barbiturates, and dissociative agents, with explanations on their pharmacodynamic mechanisms. The textbook further elaborates on narcotic and non-narcotic analgesics, emphasizing SAR, classification, and mechanisms of morphine analogs and opioid antagonists. The book concludes with a thorough discussion on anti-inflammatory agents, both steroidal and non-steroidal, highlighting important compounds like aspirin, ibuprofen, and diclofenac. This textbook integrates chemical structures, pharmacological profiles, and therapeutic applications, making it a valuable resource for undergraduate students. It also serves as a reference for postgraduate learners and professionals seeking foundational knowledge of drug design and development. The inclusion of SAR for each drug class enhances understanding of how structural changes influence pharmacological action. Each chapter is supported by up-to-date examples, reinforcing clinical relevance. With its detailed content and organized layout, this book is essential for students aiming to excel in medicinal chemistry and related pharmaceutical sciences.


About Author

Mr. Padol Shubham Gambhirrao currently working as HOD at Adsul College of Pharmacy, Chas Tal/Dist. Ahilyanagar. He has completed his D. Pharm from Mahatma Gandhi Vidya Mandir, Nashik, Maharashtra & B. Pharm from SSR College of Pharmacy, Silvassa, Maharashtra. He holds a Master of Pharmacy Degree in Pharmaceutical Quality Assurance from SND College of Pharmacy, Yeola, Maharashtra. He has 1 year of Experience in Academics and research. Also attended various National and International Seminar/Conferences and also presented research work in oral and poster competition. He has published 2 research and 05 review articles in various National and International journals of repute and also patent. Ramakant Kashyap is an accomplished academician in the field of pharmaceutical sciences. He completed his B.Pharm from RBMI, Bareilly, and earned his M.Pharm from IFTM University, Moradabad, Uttar Pradesh. Currently, he serves as an Assistant Professor in the Department of Pharmacy at Future University, Bareilly, with over five years of teaching experience. He is actively pursuing a Ph.D. in Pharmaceutical Sciences, contributing significantly to research and innovation. Mr. Kashyap has authored more than 10 research papers, patents, and review articles published in reputed national and international journals. His areas of interest include drug formulation, pharmacological screening, and novel drug delivery systems. Moni Rawat, M.Pharm in Pharmaceutical Chemistry from Dr. A.P.J. Abdul Kalam Technical University (Lucknow), combines academic insight with practical know-how. With two years of industry and research experience, she brings both rigor and innovation to her work. As an Assistant Professor at Goel Institute of Pharmacy and Sciences in Lucknow, she actively mentors students, guiding them toward meaningful careers in pharmaceuticals. Her research contributions are published in Scopus-indexed journals, showcasing her commitment to advancing science. Drawing on her dual exposure to academia and industry, Moni’s work bridges theory and practice, enriching both her teaching and scholarly output. Babita holds an M.Pharm in Pharmaceutical Chemistry from Banasthali University, Rajasthan, and brings over six years of teaching experience in her field of specialization. Currently serving as an Assistant Professor at Starex University, Gurgaon, Haryana, she is deeply engaged in both academic instruction and student mentorship. Her work extends beyond the classroom, with contributions to research through published papers and a granted patent. She has guided numerous students, helping shape their academic and professional futures. With a strong foundation in pharmaceutical chemistry, Babita integrates innovation and applied knowledge into her teaching. Her dedication to research and education reflects a passion for advancing the pharmaceutical sciences. Dr. Virendra Kumar Patel, Professor and Principal College of Pharmacy, RKDF University, Bhopal (M.P.) India. He is actively engaged in research and has published on 12 articles in International and national journal. He has having 10 Indian patent and 03 International patents and also published 02 book and 03 book chapter. On his name 05 PG students and 06 research scholars register under his guidance. He is life member of various societies Viz APTI, IPA. His area of research includes drug design and discovery synthesis and Medicinal Chemistry and Analytical and Bio Analytical Chemistry and Nutraceuticals.

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