TEXT BOOK OF MEDICINAL CHEMISTRY-I

About Book

The Textbook of Medicinal Chemistry - I is a comprehensive guide designed for students and professionals in the field of pharmaceutical sciences. It provides a detailed understanding of the chemical, pharmacological, and therapeutic aspects of medicinal compounds. The book begins with an introduction to medicinal chemistry, discussing its historical development and the importance of physicochemical properties such as ionization, solubility, partition coefficient, and stereochemistry in drug action. A dedicated section on drug metabolism explains Phase I and Phase II reactions, along with factors affecting drug metabolism. The book extensively covers drugs acting on the autonomic nervous system (ANS), including adrenergic and cholinergic neurotransmitters, their receptors, and their pharmacological implications. The adrenergic system is explored in-depth, covering sympathomimetic agents, adrenergic blockers, and their structure-activity relationships (SARs). Similarly, cholinergic neurotransmission, parasympathomimetic agents, cholinergic blockers, and their clinical significance are discussed. It also provides a thorough insight into sedatives, hypnotics, and antipsychotics, including benzodiazepines, barbiturates, and antipsychotic agents like phenothiazines and butyrophenones. The SARs of these drug classes are extensively analyzed to explain their pharmacological actions. The section on anticonvulsants discusses barbiturates, hydantoins, succinimides, and benzodiazepines, detailing their mechanisms of action and clinical applications. The book also explores general anesthetics, their classification, mechanism, and uses in surgical procedures. A detailed discussion on narcotic and non-narcotic analgesics highlights opioids, NSAIDs, and their SARs, explaining their role in pain management and inflammation control. With its structured approach, detailed explanations, and emphasis on SARs, this textbook serves as an indispensable resource for pharmacy, medical