About Book
Pharmaceutical Organic Chemistry I provides a comprehensive foundation in the fundamental principles of organic chemistry essential for understanding pharmaceutical sciences. The book introduces students to the structure, nomenclature, preparation, properties, reactions, and mechanisms of important classes of organic compounds, with particular emphasis on their pharmaceutical relevance.
The book begins with aliphatic saturated and unsaturated hydrocarbons, covering alkanes, cycloalkanes, alkenes, and conjugated dienes, along with important concepts such as free-radical substitution, electrophilic addition, Markovnikov’s and anti-Markovnikov’s rules, ozonolysis, conformational theories, and the Diels–Alder reaction. It further discusses alkyl halides, emphasizing nucleophilic substitution and elimination reactions, their mechanisms, kinetics, stereochemistry, and factors influencing reaction pathways.
The subsequent chapters focus on benzene and its derivatives, introducing aromaticity, resonance, molecular orbital concepts, Hückel’s rule, electrophilic aromatic substitution reactions, and the influence of substituents on reactivity and orientation. The final section deals with carbonyl compounds, particularly aldehydes and ketones, including their preparation, properties, nucleophilic addition, condensation reactions, oxidation and reduction reactions.
Throughout the book, theoretical concepts are connected with pharmaceutical applications through examples such as liquid paraffin, soft paraffin, hard paraffin, chloral, paraldehyde, and ketoprofen. Mechanistic explanations and representative reactions are presented to develop students’ conceptual understanding and ability to predict organic transformations.
The book is designed to serve as a fundamental learning resource for B.Pharm students, helping them develop the chemical knowledge required for subsequent courses in medicinal chemistry, pharmaceutical analysis, pharmacology, and drug design. It also provides a strong foundation for understanding the relationship between chemical structure, reactivity, and pharmaceutical activity.
About Author
Dr. Sunita Mishra is a Professor in the Department of Pharmaceutical Chemistry at the College of Pharmaceutical Sciences, Puri, Odisha. She holds a Ph.D. from Siksha 'O' Anusandhan University, India. She was awarded the prestigious Canadian Commonwealth Exchange Fellowship in recognition of her academic excellence. Dr. Mishra has also completed a Diploma in Management from Xavier Institute of Management, Bhubaneswar. She is a recipient of the Best Research Scholar Award from APP American International Branch, reflecting her significant contributions to pharmaceutical research and academic leadership.
2 Dr. Ayesha Aktar Khanam Choudhury is an Assistant Professor at the Royal School of Pharmacy, The Assam Royal Global University, Guwahati, India. She holds a Ph.D. in Pharmaceutical Sciences, specializing in Pharmaceutical Chemistry. Her research focuses on medicinal chemistry, antimalarial drug discovery, heterocyclic synthesis, molecular docking, molecular dynamics simulation, and computer-aided drug design. She has experience in teaching, research supervision, scientific writing, and academic administration. Her current interests include hybrid drug design, targeted therapeutics, natural-product research, and the development of novel bioactive molecules for infectious and complex diseases worldwide today.
3 Koushik Dutta completed his B. Pharm from Dr. B. C. Roy College of Pharmacy & Allied Health Sciences, Durgapur, West Bengal. He is currently in final year of M. Pharm in Pharmaceutical Chemistry from Gitanjali College of Pharmacy, Lohapur, Birbhum, West Bengal. Previously he had worked as lecturer at Swadhin Pharmacy College, Bolpur, Birbhum, West Bengal. He has attended 2 workshops at international level in UAE. Along with it he has presented multiple research papers in National & International Conferences His academic interests include medicinal chemistry, pharmaceutical analysis, heterocyclic chemistry.
4 Dr. Ankita Wal is a distinguished academician, researcher, Professor, and Head of the Department at PSIT, Pharmacy, Uttar Pradesh. With her unwavering commitment to pharmaceutical education and research excellence, Dr. Wal has emerged as a pivotal figure in shaping the future of pharmacy professionals through her academic leadership, innovative thinking, and research-oriented approach. She holds five Utility patents, four of which have been successfully commercialized. She has completed research projects sponsored by prestigious agencies such as the Indian Council of Medical Research (ICMR) and the Department of Science and Technology (DST). To date, she has
published more than 100 research papers in reputed journals including Elsevier, Springer, and Bentham Science, and has authored 10 books.
