About Book
Pharmaceutical Organic Chemistry I provides a comprehensive foundation in the fundamental principles of organic chemistry essential for understanding pharmaceutical sciences. The book introduces students to the structure, nomenclature, preparation, properties, reactions, and mechanisms of important classes of organic compounds, with particular emphasis on their pharmaceutical relevance. The book begins with aliphatic saturated and unsaturated hydrocarbons, covering alkanes, cycloalkanes, alkenes, and conjugated dienes, along with important concepts such as free-radical substitution, electrophilic addition, Markovnikov’s and anti-Markovnikov’s rules, ozonolysis, conformational theories, and the Diels–Alder reaction. It further discusses alkyl halides, emphasizing nucleophilic substitution and elimination reactions, their mechanisms, kinetics, stereochemistry, and factors influencing reaction pathways. The subsequent chapters focus on benzene and its derivatives, introducing aromaticity, resonance, molecular orbital concepts, Hückel’s rule, electrophilic aromatic substitution reactions, and the influence of substituents on reactivity and orientation. The final section deals with carbonyl compounds, particularly aldehydes and ketones, including their preparation, properties, nucleophilic addition, condensation reactions, oxidation and reduction reactions.
Throughout the book, theoretical concepts are connected with pharmaceutical applications through examples such as liquid paraffin, soft paraffin, hard paraffin, chloral, paraldehyde, and ketoprofen. Mechanistic explanations and representative reactions are presented to develop students’ conceptual understanding and ability to predict organic transformations. The book is designed to serve as a fundamental learning resource for B.Pharm students, helping them develop the chemical knowledge required for subsequent courses in medicinal chemistry, pharmaceutical analysis, pharmacology, and drug design. It also provides a strong foundation for understanding the relationship between chemical structure, reactivity, and pharmaceutical activity.
About Author
1. Dr. Manojkumar K. Munde is a Professor at SNBP College of Pharmacy, Chikhali, Pune with more than 18 years of academic experience in pharmaceutical education and research. He specializes in Pharmaceutical Chemistry and holds M.Pharm and PhD qualifications, along with a Diploma in Intellectual Property Rights (IPR). With a strong commitment to teaching, research, and academic development, he has guided more than 30 undergraduate and over 5 postgraduate students in their academic and research projects. He is currently guiding 2 PhD scholars in Pharmaceutical Sciences. Dr. Munde has published more than 25 research papers in reputed international journals indexed in Scopus and Web of Science. His academic interests include pharmaceutical chemistry, research, innovation, and intellectual property rights.
Dr. Rahul H. Khiste is a HOD and Professor of Pharmaceutical Chemistry at MGM School of Pharmacy, Mumbai with extensive experience in teaching, research, and academic administration. He holds a Ph.D. in Pharmaceutical Sciences from NIMS University, Jaipur, an M. Pharm in Pharmaceutical Chemistry, a B. Pharm, and a Post Graduate Diploma in Patent Law from NALSAR University of Law, Hyderabad. He has 18 years of teaching and 8 years of industry experience. His research interests include pharmaceutical chemistry, drug design, analytical techniques, and medicinal chemistry. He has guided 18 M. Pharm students, published numerous research papers, and contributed to patents. He has also actively participated in accreditation, industry collaboration, entrepreneurship, intellectual property awareness, and faculty development activities.
2. Mr. Hemant P. Alhat working as Associate Professor, Dept Pharmaceutical chemistry PES Modern college of Pharmacy, Moshi. He holds a rich academic and Researcher experience of 20 years. He has completed research project, secured research grants from BCUD, Savitribai Phule Pune University, Pune. With extensive experience in pharmacy higher education, curriculum design, and laboratory instruction, their work bridges core medicinal chemistry principles with advanced analytical methodologies, regulatory considerations, and modern computational applications. Their research focuses on pharmaceutical analysis, drug design, and impurity profiling—including critical insights into nitrosamine contaminants and stability evaluation.
3. Dr. Devidas S. Naik is an Assistant Professor at SBNM College of Pharmacy, Mahad, Raigad with more than 6 years of academic experience in pharmaceutical education and research. He specializes in Qallity Assurance and holds M.Pharm and PhD qualifications, along with a Diploma in Intellectual Property Rights (IPR). With a strong commitment to teaching, research, and academic development, he has contributed significantly to pharmaceutical education. Dr. Devidas Naik has published more than 6 research papers in reputed international journals indexed in Scopus and Web of Science. His academic interests include pharmaceutical chemistry, research, innovation, and intellectual property rights.
